Strip away the industry labels and high-margin businesses share four traits. First, low cost of delivery: what you sell is mostly your expertise, software, or information, not physical stuff you have to buy, store, and ship. The closer your product gets to bits and brainpower, the less each sale costs you and the more of the price you keep. Second, low overhead: no premises, no payroll, no inventory sitting in a garage depreciating. Overhead is the silent margin-killer, every fixed cost is a number you have to clear before you earn a cent.
Third, recurring revenue, or at least repeat revenue. A business where customers pay again, a subscription, a retainer, a refill, spreads the cost of winning them across many payments instead of one. A one-time sale has to be profitable enough to cover the entire cost of acquisition in a single shot, which is a brutally high bar. Fourth, pricing power: you're solving an urgent, valuable problem, not selling a commodity where the only lever is being cheaper than the next person. Painkillers command prices, commodities race to the bottom.
Hold any idea against those four. The more of them it has, low delivery cost, low overhead, recurring revenue, real pricing power, the more profitable it is by construction, before you've sold a single unit. The fewer it has, the harder you'll work for every point of margin.